Each year students request frameworks for the few subjects that don't perfectly fall into the standard bread & butter clinical pathophysiology framework which most of the Step 1 material generally falls into.

The "difficult frameworks" that are most frequently requested are Biochem-Genetics, Clinical Pharm, Micro, and Renal Phys. We've gone ahead and designed these frameworks - i.e., the key "pillars of knowledge" that represent the fundamental info that's tested on the Step 1 exam. (Italicized are the topic-specific changes relative to the "basic framework").

Recall the bread & butter S1M Basic Framework for clinical pathophysiology:










And the advanced frameworks with corresponding examples...




















Clinical Pharmacology:


















Renal Physiology (acids, bases, electrolytes):



















And Clinical Microbiology:


















A note about the Clinical Micro Framework and its use: this subject is best studied in a Systems-Oriented format, as the “Exposure/Presentation” aspect of the framework will always represent a “Mechanism/Pathogenesis” for another Organ System (e.g., S. Pneumo as the mech/path for the “bacterial meningitis” framework within neurology). Rather than memorizing all clinical presentations / exposures associated with a particular bug, when you study a disease in the Clinical Pathophysiology framework with an infectious agent as its "mech/path," use that as an opportunity to go back and review that particular organism's framework as part of free association.